Bioequivalence and Bioavailability
Bioequivalence refers to the similarity in the rate and extent of drug absorption between a generic and brand-name drug. It is assessed through comparative pharmacokinetic studies to ensure the generic drug performs similarly to the original. Bioavailability measures the proportion of the drug that reaches systemic circulation and is available to produce its desired effect. Factors affecting bioavailability include drug formulation, route of administration, and patient-specific factors like metabolism and gastrointestinal conditions.
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